Recombinant Human/Murine/Rat Activin A (rHu/Mu/RtActivinA)
英文全名
Recombinant Human/Murine/Rat Activin A (rHu/Mu/RtActivinA)
英文别名
蛋白结构
氨基酸序列
Accession
Gene ID
产品英文概述
Activins and Inhibins are TGF-beta superfamily cytokines that are involved in tissue morphogenesis and repair, fibrosis, inflammation, neural development, hematopoiesis, reproductive system function, and carcinogenesis. Activin A protects the heart from hypoxic stress and promotes the differentiation of embryonic stem cells into cardiomyocytes. Activins are homodimers or heterodimers of various beta subunits (betaA, betaB, betaC, and betaE), while Inhibins are heterodimers of a unique alpha subunit and one of the beta subunits. Activin A is a homodimer of two betaA chains. Human betaA shares 100% amino acid sequence identity with mouse, rat, bovine, porcine, and feline betaA. Activin A binds to Activin RIIA which then associates with Activin RIB/ALK-4. Activin A bioactivity is regulated by cell-associated molecules (BAMBI, Betaglycan, and Cripto) and soluble molecules (beta2-Macroglobulin, Follistatin, and FLRG).
来源
Chinese Hamster Ovary cell line, CHO
分子量
生物活性
Measured by its ability to induce hemoglobin expression in K562 human chronic myelogenous leukemia cells. The ED50 for this effect is 0.2-1.2 ng/mL.The specific activity of Recombinant Human/Murine/Rat Activin A is approximately 1 IU/ug, which is calibrated against human Activin A WHO International Standard.
外观
Sterile Filtered White lyophilized (freeze-dried) powder.
配方
Lyophilized from 0.2 um filtered concentrated solution in 30 % acetonitrile and 0.1 % TFA.
内毒素
Less than 0.01 EU/ug of rHu/Mu/RtActivin A as determined by LAL method.
溶解说明
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile 4 mM HCl to a concentration of 0.1-0.5 mg/ml. Further dilutions should be made in appropriately buffered solutions.
储存条件
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.- 12 months from date of receipt, -20 to -70 °C as supplied.- 1 month, 2 to 8 °C under sterile conditions after reconstitution.- 3 months, -20 to -70 °C under sterile conditions after reconstitution.
参考资料
纯度
> 95 % by SDS-PAGE analyses.
SDS-PAGE电泳
包装规格
10ug
安全数据表下载 (SDS)
技术参数表下载 (TDS)
品牌链接
Recombinant Human/Murine/Rat Activin A是ChemWhat品牌授权产品并通过沃尔森销售，下面是ChemWhat上的该产品链接 Recombinant Human/Murine/Rat Activin A (rHu/Mu/RtActivinA)
