Recombinant Human Parathyroid Hormone 1-34 (rHuPTH1-34)
英文全名
Recombinant Human Parathyroid Hormone 1-34 (rHuPTH1-34)
英文别名
Parathormone, Parathyrin
蛋白结构
氨基酸序列
SVSEIQLMHN LGKHLNSMER VEWLRKKLQD VHNF
Accession
Gene ID
产品英文概述
Parathyroid hormone (PTH) is a single polypeptide of 84 amino acids. PTH is a critical hormone in the regulation of Ca2+ homeostasis. PTH is secreted by the parathyroid glands, which promote release of calcium from bone to extracellular fluid by activating osteoblasts and inhibiting osteoclasts, indirectly promote increased intestinal absorption of calcium, and promote renal tubular reabsorption of calcium and increased renal excretion of phosphates. It is a major regulator of bone metabolism. Secretion of parathyroid hormone increases when the level of calcium in the extracellular fluid is low.
The amino terminal (1-34) fragment of parathyroid hormone, called PTH (1-34)
reproduces all the activity of the full length mature hormone and has been used therapeutically for treatment of osteoporosis.
来源
Escherichia coli.
分子量
Approximately 4.1 kDa, a single non-glycosylated polypeptide chain containing 34 amino acids.
生物活性
Fully biologically active when compared to standard. The ED50 as determined by its ability to induce cAMP accumulation in murine MC3T3E1 cells is less than 50 ng/ml, corresponding to a specific activity of > 2.0 × 104 IU/mg.
外观
Sterile filtered white lyophilized (freeze-dried) powder.
配方
Lyophilized from a 0.2 um filtered concentrated solution in PBS, pH 7.0.
内毒素
Less than 1 EU/ug of rHuPTH1-34 as determined by LAL method.
溶解说明
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存条件
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.- 12 months from date of receipt, -20 to -70 °C as supplied.- 1 month, 2 to 8 °C under sterile conditions after reconstitution.- 3 months, -20 to -70 °C under sterile conditions after reconstitution.
参考资料
纯度
> 97% by SDS-PAGE and HPLC analyses.
SDS-PAGE电泳
包装规格
100ug/500ug
安全数据表下载 (SDS)
技术参数表下载 (TDS)
品牌链接
Recombinant Human Parathyroid Hormone 1-34是ChemWhat品牌授权产品并通过沃尔森销售，下面是ChemWhat上的该产品链接 Recombinant Human Parathyroid Hormone 1-34 (rHuPTH1-34)
